Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
نویسندگان
چکیده
منابع مشابه
Glucocerebrosidase Involvement in Parkinson Disease and Other Synucleinopathies
Mutations in both copies (homozygous or compound heterozygous) of the gene encoding the lysosomal enzyme glucocerebrosidase, which cleaves the glycolipid glucocerebroside into glucose and ceramide cause Gaucher disease. However, multiple independent studies have also reported an association between GBA mutations and Parkinsonism with an increased frequency of heterozygous GBA mutations in vario...
متن کامل[Autonomic disturbances in Parkinson disease].
The current concept of Parkinson disease comprises a group of non-motor symptoms. Among these, dysautonomia is a common problem that deteriorates the quality of life of patients. In this article we review the most common dysautonomic manifestations that are observed in cardiovascular, gastrointestinal, urinary, genital and skin systems. Their possible role as risk factors, premotor symptoms and...
متن کاملReduced autonomic activity in Parkinson disease patients.
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متن کاملAssociation Between Autonomic Impairment and Structural Deficit in Parkinson Disease
Patients with Parkinson disease (PD) have impaired autonomic function and altered brain structure. This study aimed to evaluate the relationship of gray matter volume (GMV) determined by voxel-based morphometry (VBM) to autonomic impairment in patients with PD. Whole-brain VBM analysis was performed on 3-dimensional T1-weighted images in 23 patients with PD and 15 sex- and age-matched healthy v...
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ژورنال
عنوان ژورنال: Movement Disorders
سال: 2018
ISSN: 0885-3185
DOI: 10.1002/mds.27344